半導体ナノ粒子を用いた腫瘍治療への応用
 
参加研究室
工学系研究科 化学システム工学科
医学系研究科 外科学専攻 腫瘍外科学分野
 
目標
ナノ粒子により腫瘍の微小転移の進展状況の正確な診断と治療法を開発し、臨床に導入することを目的とする。
診断面では、肉眼的に確認不能な腹膜播種・微小転移を視覚化して、手術や治療方針の決定に応用する。
治療面では、ナノ粒子を細胞に取り込ませることにより起こる細胞内の変化を用いて、腫瘍の新しい治療法を追求する。
 
研究領域
腫瘍診断学
腫瘍治療学
外科学
 
 
Affiliated Department
Department of Chemical System Engineering
Department of Surgical Oncology
 
Objects
To develop an exact diagnosis and treatment system for the micro-metastasis of neoplasm by using nano-crystal particles, and to introduce it to clinical use.
To visualize peritoneum metastases (peritonitis) and micro-metastasis of neoplasm which cannot be checked in naked eye, and apply it to an operation or the determination of a medical treatment plan.
To search for the new method for treating neoplasm by using biological changes of the cells after up taking nano-crystal particles.
 
Major Research Projects
Surgical Oncology
Digestive Surgery
Surgery
 
Tel. 03-5800-8653
E-mail : nagawa-1su@h.u-tokyo.ac.jp
 
成果(Results)
 
図1
 
図2
     
Fig.1 Colon cancer cell line HCT116 was incubated with medium containing cysteamine coated orange-emitting CdSe QDs (emission: 600nm) for overnight. QDs were up-taken into the cells by endocytosis.   Fig. 2 Colon cancer cell line WiDR was incubated with cysteamine coated orange-emitting CdSe QDs and up-taken. Then, they were fixed and labeled by anti-Actin antibody and green-emitting QDs.